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SCIENTIFIC STUDIES ON INGREDIENTS

1. LODHRA (Symplocos racemosa)

 

Lodhra is an important medicinal plant mentioned in Ayurvedic classics and Nighandus for the treatment of Raktapitta(Bleeding disorder ), pradara(Leucorrhoea ) and sotha (Inflammation). Stembark is a useful part of this drug. Raktapitta is a pittaprakopak & Rakthapradhooshak vyadhi.

Ayurvedic texts

  1. Charaka Samhita-sonata sthapana(arrest bleeding ), sandhaniya (promotes healing)
  2. Sushruta samhita-38th chapter of sutrasthana of susruta samhitha known as Dravya samgrhaniya adhyaya and divided into 37 subgroups Lodhradi gana(6th) and Nygrodhadi gana(24th) have been mentioned. Lodhradi gana has the meda Kapha har yonidhosha har, Stambi, vranya, and vishanasana action.
  3. Ashtanga Hridaya – Rodhradi, and Nygrodhadigana both are mentioned in the 15th chapter of sutrasthana ‘Sodhanadigana sangraha adhyaya’ and indicted for correction of abnormal meda and Kapha, Stambhak le, which stop the bleeding or Secretion due to their dry, light, cooling properties and astringent taste, Varnahita (beneficial for Complexion) and vishagna ie; an antidote to poisons.

25 grams of bark of lodhra should be boiled in 200m. L water & reduced into 50ml This Kashaya will be helpful for uterus-related diseases menorrhagia & leucorrhea

 

2. Ashoka (Saraca asoca)

 

Saraca asoca has been greatly used as traditional medicine for women-related Problems, such as leucorrhoea, menorrhagia dysfunctional uterine bleeding, and bleeding hemorrhoids etc. It is also effectively used in Ayurveda for clearing congestion. from the medas dhatus and mamsa especially when there may be leucorrhoea, endometriosis, cyst, and fibroids from excess Kapha and ama in Artava srotas.

The Asoka herb also has a nourishing effect on the circulatory system thereby making it an effective remedy in arrhythmia and cardiac weakness. The herb also helps in encouraging urine flow and thus helps in treating conditions that cause painful urination. The Ashoka herb benefits the endometrium and uterine muscles and this makes it effective as a uterine tonic for irregular menstrual cycles and miscarriage.

In Pradara Roga of females, Ksheera paka of its 6 gm bark powder should be taken. It is so effective in all types of abnormal discharges per vagina. Ksheerapaka is also beneficial in uterine inertia, uterine pain, urinary calculus, dysuria. In pain, its paste of bark should be applied on that site. The women folk of Chhattisgarh boil the bark of Ashoka in cow’s milk, add sugar, and consume it once a day for three days and repeat the course after 3 months to prevent gynecological disorders.

In menorrhagia, the healers boil the bark in water and prepare a decoction. In this decoction, many other herbs are added. This decoction is given every morning to patients(On an empty stomach). Many healers boil the bark in milk also. The decoction is also used externally for washing. In the case of leucorrhoea, the healers boil the bark in a mixture of milk & water. When water evaporates the combination is given to the patients.

Antimenorrhagic activity

Ashoka dried bark has been used for menorrhagia in India. In India Saraca asoca dried bark as well as flower is given as a tonic to Ladies in case of uterine disorder. Saraca asoca Stem bark is also used to treat all disorders associated with the menstrual cycle. Ashoka bark in India is used as uterine Sedative and hot water extracts administered to human adult females stimulate the uterus similar to ergot, But without producing tonic contraction.

Also employed in menorrhagia as an emmenagogue, uterine sedative, and uterine affections as well as used in several preparations related to female troubles.

Saraca asoka in India, dried bark used as an astringent in menorrhagia to Stop excessive uterine bleeding, also as a refrigerant, demulcent, for uterine disorders, regular menstrual pain in the abdomen, used for uterine problems.

Uterine tonic activity

Saraca asoca is outstanding in ayurvedic medicine for its use as a stimulant to the endometrium and ovarian tissue. The estrogenic effect of U-3107 was considered in normal and Ovariectomised rats. U-3107 was administered as an aqueous suspension for 21 days. The management of ovariectomized rats did not expand on uterine weight. U-3107 holds est orogenic activity only in the presence of a functional ovary and is devoid of any progestational activity. U-3107 is an herbal preparation formulated with different plant extracts that are useful in a variety of menstrual disorders. such as puberty, menorrhagia, dysmenorrhea, premenstrual syndrome, abnormal bleeding, and threatened abortion.

 

3. Kanchnar( Bauhinia variegata)

 

Kanchnar bark is used in disorders like Gandamala (Lymphadenopathy), Goitre, BPH, and Kapha-Pitta dosha disorders. while flowers have pittaghna, Rakta pradaraghna (Cures Dysfunctional uterine bleeding).

Also, it has the property of anti-inflammatory activity & analgesic activity. It was reported to show anti-inflammatory and analgesic activity. It was found to have a new triterpene saponin in Its leaves that decreases Oedema, followed by a significant decrease in prostaglandin Ez (PGEZ) Levels in granuloma, liver homogenate, and serum. It also shows analgesic effects in central and visceral nociceptive mouse models

The flower of Kachnar consists Of flavonoids, kaempferol-3-galactoside, and Kaempferol-3- rhamnoglucoside and buds decoction is given in menorrhagia Kanchanara pushpa chorna, orally 12 gram in three divided doses empty Stomach for 3 consecutive cycles for 1st 5 days of menstrual flow with Tandalodaka (30ml) in Asrigdara. The Treatment is done for 3 months The response to the treatment is recorded and therapeutic effects were evaluated with the help of symptomatic relief.

 

4. Kaiphala (Myrica nagi)

 

Myrica nagi has been traditionally used for the treatment of various disorders such as fever, anemia, chronic dysentery, and inflammation.

Research articles related to myrıca nagi

Anti-inflammatory action:- The present Study evaluated the anti-inflammatory activity of ethyl acetate and aqueous extracts of bark of M.nagi using carrageenan and histamine-induced rat paw edema 25% and 18% respectively than the Standard drug (27%) when rats were challenged with histamine-induced rat paw edema.

Systemic Action

External- Bark is one of the strong Sirovirechana herbs that helps to expel vitiated doshas from the Scalp and upper part of the chest region. Antipruritic and anti-inflammatory help to constrict the uterine muscles. Its powder can be tied into a cloth and applied to the vaginal area to facilitate uterine contraction.

 

5. Bombax ceiba(Mochras )

In the Unani system of medicine more emphasis is given to the use of gummy exudates known as mochras obtained from its branches and Stem. It has an astringent action on the uterus if kept in the vagina as a pessary, thus used in leucorrhoea.

To reduce or stop puerperal discharge and menorrhagia mochras is used with rasot orally.

Ethanolic extract of Bombax ceiba bark and flower was given for 3 days for various diseases like gonorrhea, leucorrhea, and menstrual disorders in women. Another study was carried out in Chittorgarh and Udaipur districts. In Rajasthan showed that bark, flower & root bark powder of this plant are used in these disorders. Apart from sexual diseases, these plant materials are also used to regularise menstruation and urinary problems (Jain et al, 2004).

Kandha tribe of Orissa uses the juice of the fresh stem bark of Bombax ceiba, Juice of the fresh root of Asparagus racemosa powder of Seven black peppers, and 1 teaspoon of sugar or gum taken orally before meals twice a day for 21 days to cure impotency, spermatorrhea, leucorrhoea (Behera and Misra, 2005).

Analgesic effect

Entracts displayed significant analgesic effects in acetic acid-induced writhing and hot plate tests in mice.

 

6. Manjuphala (Quercus infectoria )

Manjuphala is used extensively as an antiseptic & hemostatic, and also used as a pacifying agent in inflammation.

  • The resin of Quercus infectoria, A. Camus is used to cure gonorrhea and hemorrhage.
  • The powder of gallnut of Q. Infectoria is used to restore the elasticity of the uterine wall.

  • Astringent effects of oak gall for vaginal tightening & rejuvenation in women with  vaginal relaxation. Here findings show that using topical jell of oak gall(Oak means   Quercus fruit)not only is associated with contracting effects but also improves vaginal lubrication and reduces its dryness. Studies suggest that oak gall is used for the management of women with vaginal relaxation.

In topical application, due to astringent effects, it is used for constriction of the vagina and anus, relieves vaginal discharge, and oozing eczema.

 

7. Supari (Areca catechu)

The Seeds of A. Catechu has been widely used in clinical practice in China India and other south and southeast Asian countries. A. Catechu has many pharmacological activities. These include antiparasitic effects, antidepressant effect, anti-fatigue effect, antihypertensive effects, anti-inflammatory and analgesic effects, suppression of platelet aggregation, regulatory effects on blood glucose and lipids, And antifertility activity, oxytocic activity, in case of leucorrhoea & urinary disorders also.

 

8. Khoonkharaba (Dracaena cinnabari)

In folk medicine it is prescribed for the treatment of traumatic dermal dental & Eye injuries as well as blood stasis, and pain.

It has properties of antiinflammatory and analgesic effect – Alwashliet al evaluated the antiinflammatory and analgesic activities of an ethanolic extract of D. Cinnabari resin using animal models and found that it significantly reduced inflammation at 50 and 150 mg/kg oral doses.

Antispasmodic and Relaxant effects:

The aqueous extract of D. Cinnabari resin has been shown to cause a concentration-dependent decrease of amplitude in phasic contractions. In albino male rats, it relaxes the tone of the longitudinal segment of the ileum, uterus, and urinary bladder rings. This observation is consistent with the reported effect of other Dracaena species and Dragon’s blood-producing plant. D. Cinnabari resin aqueous extract may be attributed to the presence of hydrophilic flavonoids in the resin since different flavonoids have been shown to exert spasmolytic effects on smooth muscles of different preparations.