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SCIENTIFIC STUDIES ON INGREDIENTS

1. Gokshura(Tribulus terrestris)

 

Its usage in Ayurveda was for impotency, poor appetite, and Jaundice. Urogenital disorders and cardiovascular diseases & it is also used for the treatment of lower back pain, sciatica, and inflammation of the pelvic & sacral region.

Effect on kidney stone:

When Tribulus terrestris itself is used in rats, it shows dose-dependent protective effects with most potency in the ethanolic extract & when unex is used( a combination formula of Tribulus Terrestris & Boerhavia diffusa) in a rat model of ethylene glycol induced kidney stones, 200 mg/kg oral ingestion can  reduce kidney stone formation with a potency comparable to 750 mg/kg cystone (400 mg/kg unex appeared to be slightly less potent.

Tribulus terrestris appears to be able to reduce kidney stone formation in vitro(specifically calcium oxalate stones )which may be due to multiple components. It has  shown efficacy in rodents, and when paired with another herb known as Boerhavia diffusa it appears to be quite potent.

Effect on prostate problems:

Tribulus has been investigated  for its benefits on BPH, although this study used a combination supplement of Tribulus Terrestris Murray Koenig. Although only 12 weeks in length, the combination supplement was able to reduce IPSS symptoms from a score of 17 down to 9, which was not significantly different than the efficacy of 400 mcg tamsulosin reducing IPSS symptoms from 14 to 8, the herbal combination on reduced prostatic volume from 33.5 m. L to 31.6 m. L and was statistically significant while the 3.4% reduction seen with tamsulosin did not reach significance. This study was criticized for its usage of generic tamsulosin (and thus no control for the active amount of tamsulosin )paired with a lack of a placebo group.

Another possible confound to the above research is that IPPS symptoms include urinary flow, as Benign prostatic Hyperplasia may sometimes reduce flow rate. Tribulus Terrestris itself appears to possess diuretic properties, although this study used a large dose of Tribulus where 5g/kg in Guinea pigs was as effective as furosemide. There are well-established instances of T. terrestris-induced neurotoxicity and renal toxicity in ruminant animals although this does not appear to extend to humans.

  • Gokshura is a potent herb that is known for its diuretic, anti-inflammatory & antioxidant properties. It helps regulate urine flow and reduce inflammation in the prostate gland

Diuretic action of Gokshura

Diuretic action of both root & fruit of Gokshura is similar in terms of urine volume, but the root is more effective based on ionic excretion. Hence while treating patients suffering from ionic imbalance, it is better to use the fruit of Gokshura to protect the ionic balance during diuresis. In all other conditions, root can be used for a better diuretic activity.

Anti-Inflammatory Activity of root and fruit of Gokshura

Root & fruit of Gokshura, showed significant anti-inflammatory activity in albino rats. But the root of  Gokshura showed a greater anti-inflammatory action in comparison to its fruit.

 

2. Ushira (vetiveria zizaniodes)

 

Ushira’s pharmacological actions are anti-inflammatory activity, antipyretic activity, Antidysentery, analgesic, anti-oxidant, & anti-arthritic activity.

  • Its diuretic properties help treat urinary tract infections
  • It helps to relieve dysuria, and urinary retention, and acts as a diuretic.

Urinary tract disorders:

This herb is highly effective in relieving urinary complaints like renal stones and UTIs. The antibacterial action produced by the herb destroys the bacteria in the urinary tract causing infections. It also provides relief from painful urination. It  produces an antispasmodic action and reduces colicky pain caused when a kidney stone tries to come down through the urinary tract.

 The drug ushira has sheeta and madhura properties. Diuretics are the drugs that cause a net loss of sodium and water in urine. These are widely prescribed drugs. They are used whenever there is a need to eliminate excess water and ions accumulated in tissue.

Because of the properties like Diuretic, anti-inflammatory & antiarthritic activities. It is used in the case of prostate gland-related problems.

 

3. Shilajit (Asphaltum)

 

Shilajit has analgesic antiinflammatory activity and is thus useful for different painful conditions of the body. Being a diuretic agent shilajit removes the excess fluid from the lungs as well as the body.

And also shilajit has an antiarthritic effect. Because of all these properties, shilajit can be used in case of prostate gland-related problems.

 

4. Guggulu (commiphora wightii)

 

Guggulu is a resin that has anti-inflammatory and anti-arthritic effects. It supports healthy cholesterol levels and reduce inflammation in the Prostate gland.

Studies have shown that the combination of 3 ingredients in Gokshuradi guggulu can have a Synergistic effect on prostate health. The anti-inflammatory properties of Guggulu and gokshura work together to reduce inflammation in the prostate gland. Several Studies have shown the potential benefits of Gokshuradi guggulu for prostate health •A 2018 study published in the Journal of Ayurveda and Integrative Medicine found that Gokshuradi Guggulu helps in reducing the symptoms of BPH, such as frequent urination, weak urine flow and incomplete bladder emptying. The study concluded that Gokshuradi Guggulu could be a useful adjunct to conventional treatment options for BPH.

Hypolipidemic activity of Guggulu

Clinical studies on c wighti showed its hypolipidemic effect and the outcome of change in lipid profile upon its administration this study showed a significant decrease In total cholesterol and LDL Cholesterol after treatment with Guggulu.

Thyroid Stimulatory activity

Administration of ethanolic extract of Guggulu to the female albino mice for 15 days enhanced the T3 concentration and T3 I T4 ratio, while no marked change in the concentration of Serum thyroxine (T4)was observed. Z-guggulSterone was shown to be responsible for the thyroid Stimulatory action of Guggulu. Administration of isolated z Guggulu Sterone to rats led to a significant increase in all “Thyroid function parameters namely uptake of iodine  by the thyroid,  enzyme  Involved in the synthesis of thyroid hormone thus suggesting thyroid Stimulatory action.

Ans-inflammatory & Antiarthritic Activity

The results of Several Studies confirm the anti-inflammatory and anti-arthritis activities of Guggulu. The 50% aqueous methanolic extract was found to exhibit an Anti-inflammatory effect on adjuvant-induced air pouch granuloma in mice

Several animal studies have demonstrated the effectiveness of Guggulu extract in standard Osteoarthritis (OA) models. The authors had Conducted both animal & clinical investigation of Guggulu For OA Before this study The goal of this study was to determine the effectiveness of Guggulu for the reduction of pain, Stiffness, and other symptoms that arise from OA

 

5. Pumpkin (Cucurbita pepo)

Many pharmacological Studies have demonstrated hepatoprotection  inhibits benign prostatic hyperplasia, is antioxidant anti-inflammatory, and anti-microbial Supporting its traditional uses

Leaves of Cucurbita pepo – Treating bladder disorder, stomach upset, intestinal worms, rheumatism, BPH

Fruits of Cucurbita pepo_effective in urinary complexities, Cardioprotective action, anti-inflammatory, used in the curing of fatness, gastric problems, irritable Bladder in Children’

C.pepo is used as a vegetable as well as in the treatment of various diseases all over the world. The most preferable plant part is seed used for the treatment of hyperplasia, prostate cancer, urinary diseases, nephritis, and bronchitis.

The fruit of the plant is used for hyperplasia and prostate cancer.

Antioxidant activity

Some antioxidants are natural and present in plant metabolites eg. in polyphenols (flavonoids, Phenolic acids) and terpenoids, and the utilization of foods that contain polyphenols and terpenoids in large amounts plays an important role in prophylaxis against many diseases. The regular use of fruits & vegetables reduces the Frequency of  cardiovascular and cancer disease methanol & ethanol extract of C. pepo Seeds have antioxidant activity. The terraced – cucurbitacine isolated from seeds shows antioxidant activity.

Hypolipidemic activity

The lipid-reducing effect of c.pepo is probably due to its fibers being inhibited. the absorption of bile acide and  cholesterol these Substances reduce plasma LDC levels and enhance the activity of LDL receptors Furthermore a fiber-rich diet reduces triglyceride levels by  suppressing lipogenesis in the liver cholesterol levels  in roots can be reduced by oleic acid and linoleic acid

 

6. Varuna (Crataeva nurvala)

The herb is also called createva zizaniodes. There are several potential benefits that Varuna may offer including. Improving urinary tract health relieving urinary symptoms OF BPH and maintaining kidney efficiency. Preventing the formation of urinary tract stones (Urolithiasis). Varuna is a herb that has been researched In multiple clinical trials and scientific Studies. The product is prevalent among people who Struggle with urinary problems.

In men  with BPH, the use of this herb may assist in reducing the symptoms the person is experiencing  Notably, the Product may ease up the urinary symptoms that  tend to develop with an enlarged prostate

Urinary tract Health

This herb can help expel excess fluids from the body. The general health of the urinary tract may also improve with the use of these supplements.

Varuna contains several natural chemicals that may be useful. These include:

  • Alkaloide
  • Triterpenes
  • Saponins
  • Plant Sterols
  • Gluco silicates
  • Flavonoids
  • Tannins

The combination of these produces anti-inflammatory effects in the human body it also provides a diuretic effect and can be useful for men with urinary Symptoms due to an enlarged prostate, The use of varuna may help to ease the symptoms caused by prostate enlargement The specific symptoms experienced should be taken into account This should be compared with the potential benefits of the vanna herb.

One Study explains that varuna can provide a reduction in two, particularly Important symptoms. The symptoms that Improved in the study consisted of the following;

  • Overactive bladder and urinary incontinence

These are two common symptoms among men with benign prostatic hyperplasia The study also explains that general lower urinary tract symptoms seem to be treatable with this plant extract.

The study lasted for eight weeks. A total  of 150 people participated In the Study. There was an improvement in several lower urinary tract symptoms.

Urinary day frequency improved. Then there was a reduction in the frequency of nocturia among the participants.

Symptoms of urinary urgency improved too. There was also an improvement in the overall quality of life among the participants. Two Other herbs were combined with varuna in the study. This herb consists of Lindera aggregate root extract and equisetum arvense stem extract.

Kidney efficiency

The use of varuna, as a diuretic may be beneficial for kidney function too. one Scientific paper explains that the plant is highly effective at preventing kidney stones.

The product helps to minimize the deposition of certain chemicals in the kidneys These chemicals are the cause of the development of kidney stones when kidney stones develop, a man may suffer Severe plain and accompanying Symptoms. The herb makes it less likely for a man to develop these kidney stones.

In cases where kidney stones have developed, Varuna may still be beneficial. The product might be able to assist in dissolving these Stone This acts as an effective treatment without the need for pharmaceutical products

Prevent the formation of Stones in the urinary tract

 In addition to kidney stones, Venuna may also be helpful for urinary tract stones This condition is often referred to as urolithiasis. Stones that develop in the Urinary tract can be just as bother Some. The symptoms may include pain and discomfort. There may also be blood in the man’s urine

The role of varuna in the treatment of urolithiasis The researchers found that varuna may be able to assist in preventing this condition in the first place. Furthermore, the use of this herb could also help to treat existing urolithiasis.

People with urolithiasis often experience a recurrence every 5 years this accounts for about 50% of all patients. In these cases, varuna may be advised as a preventative strategy.