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SCIENTIFIC STUDIES ON INGREDIENTS

1. Shunti (zingiber officinalis )

 

Ginger is also used as a home remedy and is of immense value in treating various gastric ailments like constipation, dyspepsia, belching, gastritis, epigastric, bloating, gastric, discomfort, gastric ulcerations, indigestion, nausea and vomiting, and Scientific studies have validated the ethnomedicinal uses of Ginger is also shown to be effective in preventing gastric ulcers induced by nonsteroidal antiinflammatory drugs( NSAIDS like indomethacin, aspirin) reserpine, ethanol, stress(hypothermic and Swimming), acetic acid and Helicobacter Pylori Induced gastric ulcerations in laboratory animals various preclinical and Clinical studies have also shown ginger to possess antiemetic effects against different emetogenic Stimuli. However, conflicting reports, especially in the Prevention of chemotherapy-induced nausea vomiting, and motion sickness, prevent us from drawing any firm conclusion on its effectiveness as a Spectrum antiemetic

Main action ginger and Anti-inflammatory, antioxidant, anti-ulcers effects of ginger have been proven in many Scientific studies, and some of the ancient applications of ginger as a home. remedy has been confirmed in humans. In this review, we summarised the current evidence on the effect of ginger consumption on gastrointestinal disorders based on clinical trials. And data indicate that a divided lower daily dosage of 1500mg ginger is beneficial for nausea relief

Gastric Emptying and Dyspepsia

Ginger is an important dietary agent which possesses Carminative effect, decreases pressure on the lower esophageal sphincter, reduces intestinal cramping and prevent dyspepsia, flatulence, and bloating, (Ali et al 2008; Chrubasilc pittler and Roufogalis (2005), loh siriwat, Rukkiat)A clinical trial investigated the effect of ginger extract on gastrointestinal motility and showed a significant increase in gastrointestinal motility in the Intervention group in comparison with the placebo (Mickleflad et al, 1999). Wu et al (2008) showed that ginger accelerates gastric emptying and stimulates antral contractions in healthy individuals. Studies on patients with functional dyspepsia have shown the same results with no alterations In the fundus dimension, gastrointestinal Symptoms, or Serum level of gut peptides such as GLP-1, motilin, and ghrelin(Hyetal 2011).

Nausea and Vomiting:

 Studies have shown that ginger at a dose of 1g/day is effective in pregnancy nausea and Vomiting with no significant side effects.

 American College of Obstetricians and Gynecologists (ACOG) and the National Institute for Health and Clinical Excellence have accepted ginger as a remedy for nausea and vomiting during early pregnancy.

 

2. Rock salt (Saindha Salt)

 

Rock salt is an excellent home remedy for digestive problems such as constipation, heartburn, bloating, stomach pain & vomiting.

 Rock salt is full of minerals and vitamins which improves digestion, promotes bowel movement, and helps to clean toxic products from the intestine. It also helps to improve the loss of appetite.. The study result suggests that rock salt can stimulate insulin in the body which prevents sugar  cravings. Rock salt can also be of help in losing weight.

Stimulates digestion:

Firstly rock salt acts as an appetizer, especially when consumed as a pinch in conjunction with a piece of fresh ginger before meals. Second, it aids digestion by helping to stimulate the salivary gland in the mouth to release amylase, an enzyme. Third, it helps to release HCl in the stomach, which breaks down our food into its absorbable or assimilable form. Salt is also one of the leading sources of chloride. Healthy chloride levels are essential for manufacturing Hcl Substituting your regular salt with organic India pink Rock salt can help to make your meals more nutritious, delicious, and digestible.

 

3. Haritaki (Terminalia chebula)

 

The antimicrobial action of T. Chebula especially on the gastrointestinal tract is considered in the supplementation of soothing to mucosal lining. Haritaki is used as a purgative, for flatulence, indigestion, gastroenteritis, and vata dosha. The ellagic acid present in T. Chebula has a potent inhibitory action on microorganisms like C. perfringens and E. Coli. It is commonly advocated for increasing gastrointestinal motility thus relieving the symptoms of gastroparesis for better bioavailability and fast absorption of the micronutrient. The presence of anthraquinone and sennoside is responsible for the purgative action.

 Ayurvedic properties of T. chebula on the gastrointestinal tract:

  •  Anulomini – Removes excess vata from the system.
  •  Shodhini- assists in natural internal cleansing.
  •  Rasayani-Nourishes and rejuvenates the tissues and promotes healthy digestion and absorption.
  •  Deepana- Ignites the digestive fire making even micronutrients available to the body.
  •  Lekhani-Haritaki scrapes out the unnecessary deposits and toxins in the body.

 The fruit pulp of Haritaki exhibited laxative activity.

T.Chebula was found to increase the percentage of gastric emptying. It was found that gallic acid and its ethyl ester. Isolated from T. chebula displayed potent antimicrobial activity against several bacteria, including methicillin-resistant strains of staphylococcus aureus. A crude extract of T. Chebula is reported to have potent and broad-spectrum antibacterial activity against human pathogenic gram-positive and gram-negative bacteria.

Although its traditional use as a laxative is well  established, Haritaki has been shown to increase gastric emptying time.

 Terminalia chebula and Abdominal Disorders:

In Ayurveda, Haritaki is the best for ‘Sroto Shodhan’ or purifying the channels of the body. It is a Yogvahini, as it is absorbed quickly thus acting on the digestive, absorptive, assimilative, and excretory processes, thus improving all the dietary imbalances. Haritaki is a stomachic, as it boosts up the functioning of the stomach and intestine and thus facilitates digestion. The laxative and tonic properties of Haritaki help in constipation and haemorrhoids As a natural laxative and purgative, it removes undigested food and accumulated toxins from the gastrointestinal tract. It strengthens and nourishes the tissues and supports the proper function of the colon, lungs, liver, and spleen. Haritaki is traditionally used as a remedy for all vata disturbances, including constipation, emaciation, flatulence, and indigestion. Based on its comprehensive properties, it promotes appetite and helps in proper digestion. It increases the frequency of stools and has the property of evacuating the bowel completely. It stimulates the liver and protects it further by expelling the excretory waste products from the intestine

 

4. Glycyrrhiza glabra (Yashtimadhu)

 

Glycyrrhiza glabra was formerly known as licorice or sweet wood. Roots of G. glabra have demulcent, antacid, antiulcer, anti-inflammatory, expectorant, tonic, laxative, and sedative properties.

Ayurveda has long-held herbs like Mulethi or licorice root in high regard for its health-boosting qualities. Consumption of a teaspoon of powdered licorice root is used in the management of constipation. Add a teaspoon of jaggery and drink it with a cup of warm water liquorice is known to promote bowel activity.

G.glabra is used as a mild laxative, antiarthritic, anti-inflammatory, antibiotic, antiulcer, and hypolipidemic agent.

Traditionally the plant has been recommended as a prophylaxis inflammatory agent during allergenic reactions. It is used as laxative,emmenagogue, contraceptive, galactagogue.

Glycyrrhiza roots are used for their demulcent and expectorant properties. It is useful in anemia, gout, flatulence, sexual debility, swelling, and bleeding for relieving pain, discomfort, and other symptoms caused by acrid matter in the stomach, G. Clara is considered one of the best remedies. It seems to remove the irritating effects of acid in a better way than alkalies. It is used by practitioners of the indigenous systems as a tonic, as a demulcent in catarrh of the genitor urinary passage, and as a mild laxative.

 

5. Cochlospermum gossypium  (Gond Katira)

It has several pharmacological activities and potential to provide health to society. It is used as an antimicrobial, anti-bacterial, anti-carcinogenic, antioxidant, and hepatoprotective activity and also as a stimulant and sedative. Plant is used in the treatment of immunity systems and memory power especially below the age of 12 years kids.

 One variety of this plant is Cochlospermum regium. It is being used for the treatment of gastritis, ulcers, arthritis, intestinal infections, gynecological infections, and skin diseases, among others. The present study aimed to evaluate the gastroprotective/antiulcer activity and the mechanism of action of hydroethanolic extract of c. regium xylopodium

Using in vitro and in vivo models. Additionally, phytochemical constituents were identified by high-performance liquid chromatography.

 The results obtained in the in vitro and in vivo experiments support the popular use of c. regium xylopodium in the treatment of gastrointestinal diseases, including those caused by H. pylori.

 

6. Foeniculum vulgare (Saunt)

Foeniculum vulgare is used in many parts of the world for the treatment of several diseases, for example, abdominal pain, antiemetic, colic in children, constipation, diarrhea, flatulence, gastralgia, gastritis, irritable colon, laxative, kidney ailment, and stomachache.

 Traditional and contemporary applications of F. vulgare: 

 Parts/preparation used

  •  Constipation –  seeds decoction
  • Seeds mixed with sugar
  •  Abdominal pain -Each plant part decoction
  • Leaf and seeds infusion
  • Leaves paste
  •  Purgative        –       Seed infusion and edible
  •  Laxative         –       Seed infusion and edible
  •  Digestive system –  Fruits decoction
  • Seed decoction
  • Whole plant

Anti Colitic activity

Essential oil of F. Vulgare regulates the motility of smooth muscles of the intestine, while at the same time, reducing intestinal gas. Alone or combined with other plant medicinals F. Vulgare is indicated in the treatment of spastic gastrointestinal disturbances. In some forms of chronic colitis in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative.

Gastrointestinal Effect

The aqueous extract of F. Vulgare showed a remarkable antiulcerogenic effect against ethanol-induced gastric lesions in rats. It was found that pretreatment with aqueous extract significantly reduced ethanol-induced gastric damage. The aqueous extract of F. Vulgare significantly reduced the whole blood malondialdehyde levels while significantly increasing nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels. Thus aqueous extract of F. Vulgare fruit had a protective effect against ethanol-induced gastric mucosal lesion in rats.

 

7. Cassia Angustifolia (Senna)

Different species of cassia including Cassia fistula, Cassia alata, and Cassia angustifolia are shown in some Studies to be as effective as common Laxatives due to anthraquinone derivative

Cassia angustifolia is mainly valued for its Cathartic Properties and is Specially useful in habitual constipation The laxative principles sennoside A and Sennoside B Isolated from leaves and pods of Senna, constitute important ingredients in purgative medicines.

Senna leaves are used for the treatment of constipation loss of appetite  hepatomegaly splenomegaly, and indigestion and are employed as a  safe purgative that increases the peristaltic movement of the colon.

The action of laxative sennoside is mainly on the lower bowel like other cathartics of the anthraquinone Series which are probably the breakdown products from primary glycosidic compounds occurring in the crude drug  after being absorbéd in the intestinal tract, the liberated active anthraquinone is excreted into the colon and stimulate the peristaltic movements of the colon by its local action upon the intestinal wall ( Kobashi et al 1980) This also results in decreased absorption Of water  and thereby a bulkier and Softer fecal mass. Changes  in the absorptive behavior of gut mucus are at least partly responsible for the laxative action of anthraquinones (Fairbairn and Moss 1970)A simple thorough evacuation is usually produced within 6-10 hrs after the oral administration of senna.

 

8. Rosa Centifolia (Gulab Pushpa)

Rosa powder or petal jam is useful in managing digestive problems like hyperacidity and diarrhea due to its anti-inflammatory properties.

Rose can be used in weight loss due to Its Deepana (appetizer) and Pachana    (Digestion) properties. It digests toxins and helps to throw them out of the body which helps to improve metabolism

The dried paste of its petals is quite effective in managing the problem of gastritis and duodenal ulcers which Can be consumed in doses of 5g along with milk.

Useful in constipation also, It’s decoction. prepared from the rose buds with a dosage of 20-30ml is beneficial

Rosehip tincture is effective as an astringent, manages the condition of diarrhea, and relieves colic pain pharmacological actions are:

The roots are useful in intestinal ulcers, rickets, hemorrhage, and diarrhea and also astringent Other properties are: -mild sedative local anesthetics, laxative, antidepressant, cardio-active.